The show will be replaced by Grant Denyer’s new game show Celebrity Name Game which launches on Monday at 6pm.
Humphries, who co-hosted Pointless with Dr Andrew Rochford, thanked viewers for their support in a message he posted on Facebook.
The day is here. The final episode. We want to thank everyone who tweeted along with the show every night. You made it special. Tune in tonight for one last hurrah.
To the little game-show that couldn't. Vale #PointlessAU. pic.twitter.com/X1PReQYzCB
“If you are reading this now, Pointless Australia has been murdered,” Humphries wrote.
“After 184 episodes, it is time for the show to be laid to rest in that great Australian quiz show graveyard alongside other unforgettable titans of the genre like Shafted, Hot Streak and Australian Jeopardy.
“Thank you to all the fans who stuck with the show through our teething period. It took me several weeks to realise that the red light meant the camera was on, so I appreciate your patience.
“Thank you to the crew who were extremely professional in the face of my incessant and needless song-and-dance numbers. And special thanks to our brilliantly funny warm-up Steve Philp for pressing play on the Spotify playlist when requested.
“Thank you to the contestants, who were the true stars of the show if you don’t include Andrew and myself.
“Thank you to the team at Ten Styling, who made me look like a million bucks. And thank you to the team in accounts who made our $2000 prize money look like $2000.
“Thank you to the team at Endemol Shine and the executives at Ten for taking a chance on a complete unknown like me. What a terrible mistake. But one for which I will always be grateful.
“And finally, thank you to Dr Andrew Rochford. Though I had hoped to be paired with Dr Harry Cooper, you became a true friend and got me through those long 5-episode shoot days.
“This whole experience has been an absolute privilege. I feel truly lucky.”
He signed off the message from “Mark ‘I’m available to host Insiders’ Humphries”.
Entertainment reporter Peter Ford broke the news in February that Pointless was going to be dropped by Channel 10.
The TV network then announced in March that Pointless will be replaced by Celebrity Name Game, a game show format which was created by former Friends star Courteney Cox and David Arquette.
Here’s how it works: Two teams of two contestants (think mum and son, best friends) get help from a celebrity as they try and describe the names of movies, singers, characters etc which are shown on a board behind them.
The show will be hosted by Grant Denyer and celebs who are set to appear on the Aussie version include I’m a Celeb’s Yvie Jones and Angie Kent, Beau Ryan and Courtney Act.